Start off 2024 with a thought-provoking article addressing the pressing challenges in endometriosis care and research. Authored by Linda Giudice, Andrew Horne and Stacey Missmer, this piece highlights the need for increased investment, interdisciplinary collaboration, and enhanced awareness. The narrow perception of endometriosis as solely a gynecologic disorder underscores the importance of broader, multidisciplinary approaches to diagnosis and treatment. The article discusses key issues inhibiting timely diagnosis and treatment, including the complex nature of the disorder and underfunding in research. This insightful commentary in the December 2023 issue of Nature Communications provides a comprehensive understanding of the issues and proposed solutions.